Next Week, July 23rd to 30th, is WordPress Backup Week and I encourage you all to backup you blogs.
I have recently started backing up my site using skippy‘s excellent wp-db-backup plugin. If you don’t want to use a plugin to do your backups Podz has some excellent instructions for setting up a cron job to do the backups.
One thing that is worth noting which ever backup route you take is that you should keep your backups off-site to be safe. What I mean by this is that using a cron job/plugin to create backups which are then emailed to an account hosted on the same server as your blog is not necessarily a wise idea.